有区别，区别如下。
一、词义不同
at our great sale：我们在大减价
例句：Come and buy your clothes at our great sale. 我们大减价期间请来购买衣服.
on sale ：我们在营业
例句：There are 32 different kinds of chocolate on sale along with the bread and cakes.
有32种不同的巧克力与面包和蛋糕一起出售。
二、时态不同
at our great sale 用在做某事之后
例句：Come and buy your clothes at our great sale. 快来买衣服，华星大减价。
on sale 是用在做某事之中
例句：There are some nice apples on sale in that shop.那家商店有些很好的苹果出售。
三、文法不同
at our great sale 表示行为，用作动词。
例句：Come and buy your clothes at our great sale.
on sale 表示状态，用作名词。
例句：The book will be on sale next month.
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